ProMIS Neurosciences to Present Preclinical Data from Alzheimer's Disease Program at AAIC 2017


Chief Development Officer Dr. Johanne Kaplan to chair session


TORONTO and CAMBRIDGE, MA, July 5, 2017 /PRNewswire/ - ProMIS Neurosciences, Inc., a biotechnology company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced the Company will present preclinical data for its lead product candidate, PMN310, at the Alzheimer's Association International Conference (AAIC) to be held in London on July 16-20.

ProMIS Neurosciences Inc. (CNW Group/ProMIS Neurosciences Inc.)

Johanne Kaplan, Ph.D., ProMIS Chief Development Officer, will present the data and chair the associated session, entitled Preclinical: Basic Therapeutics - Targeting Amyloid or Tau.

The presentation by Kaplan (et al.), entitled Targeting of toxic amyloid-beta oligomer species by monoclonal antibody PMN310:  Precision drug design for Alzheimer's disease describes the use of ProMIS' proprietary discovery engine for the identification and generation of monoclonal antibodies against specific targets on toxic forms of amyloid beta (Ab), a recognized root cause of Alzheimer's.

Commenting on the presentation, Dr. Kaplan stated, "Antibody PMN310 was selected as our lead product for development on the basis of its ability to selectively target and neutralize toxic Ab oligomers with no significant off-target binding to Ab monomers or fibrils. These characteristics distinguish PMN310 from other Ab antibodies currently undergoing clinical trials, and are designed to achieve optimal efficacy and safety".

ProMIS is very pleased to contribute to this year's AAIC, the world's largest forum where international investigators, clinicians and care providers gather to share the latest study results, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

The session and presentation details are as follows:

Session: Preclinical: Basic Therapeutics - Targeting Amyloid or Tau
Presentation: Targeting of toxic amyloid-beta oligomer species by monoclonal antibody PMN310:  Precision drug design for Alzheimer's disease
Date/Time of session: 4:15-5:45 PM, July 17, 2017
Location: ExCel, London, Royal Victoria Dock

About ProMIS Neurosciences, Inc.

ProMIS Neurosciences is a TSX listed biotech company (trading symbol: PMN.TO), headquartered in Toronto, Ontario and with offices in Cambridge, Massachusetts. The mission of ProMIS is to discover and develop precision medicine therapeutics for effective treatment of neurodegenerative diseases, in particular Alzheimer's disease and ALS.

ProMIS Neurosciences' proprietary target discovery engine is based on the use of two, complementary techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique "precision medicine" approach, ProMIS Neurosciences is developing novel antibody therapeutics and specific companion diagnostics for Alzheimer's disease and ALS. The company has also developed two proprietary technologies to specifically identify very low levels of misfolded proteins in a biological sample. In addition, ProMIS Neurosciences owns a portfolio of therapeutic and diagnostic patents relating to misfolded SOD1 in ALS, and currently has a preclinical monoclonal antibody therapeutic against this target.

The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release may contain certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company's current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

For further information please consult the Company's website at:

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SOURCE ProMIS Neurosciences Inc.