VIA EDGAR

November 8, 2022

Office of Life Sciences

Division of Corporation Finance

United States Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549

Attention: Tyler Howes

Re: ProMIS Neurosciences Inc.

Acceleration Request for Registration Statement on Form S-1, as amended 

File No. 333-268103

Requested Date: November 9, 2022

Requested Time: 5:00 p.m. Eastern Standard Time

Dear Mr. Howes:

Pursuant to Rule 461 under the Securities Act of 1933, as amended (the “Act”), ProMIS Neurosciences Inc. (the “Company”) hereby requests that the effective date of the above-referenced registration statement (the “Registration Statement”) be accelerated to November 9, 2022, at 5:00 p.m., Eastern Time, or as soon thereafter as practicable, unless we or our outside counsel, Troutman Pepper Hamilton Sanders LLP, request by telephone that such Registration Statement be declared effective at some other time.

Please contact Thomas Rose of Troutman Pepper Hamilton Sanders LLP, counsel to the Company, at (757) 687-7715 to provide notice of effectiveness, or if you have any questions or comments concerning this request. Thank you for your assistance.

[remainder of page left intentionally blank]