FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  WYMAN WILLIAM W
2. Date of Event Requiring Statement (Month/Day/Year)
07/07/2022
3. Issuer Name and Ticker or Trading Symbol
ProMIS Neurosciences Inc. [PMN]
(Last)
(First)
(Middle)
C/O PROMIS NEUROSCIENCES, INC., 1920 YONGE STREET, SUITE 200
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

TORONTO, A6 M4S 3E2
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Shares 62,937
D
 

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Option (right to buy)   (2) 03/08/2024 Common Shares 3,333 $ 4.8 (1) D  
Option (right to buy)   (3) 10/07/2025 Common Shares 4,167 $ 4.89 (1) D  
Option (right to buy)   (4) 09/19/2026 Common Shares 4,167 $ 9.6 (1) D  
Option (right to buy)   (5) 03/30/2031 Common Shares 8,333 $ 10.2 (1) D  
Warrants (right to buy) 04/30/2018 04/30/2023 Common Shares 2,778 $ 28.8 (1) D  
Warrants (right to buy) 02/05/2021 03/05/2026 Common Shares 4,549 $ 12 (1) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
WYMAN WILLIAM W
C/O PROMIS NEUROSCIENCES
INC., 1920 YONGE STREET, SUITE 200
TORONTO, A6 M4S 3E2
  X      

Signatures

/s/ Jason L. Langford, Attorney-in-Fact for William W. Wyman 07/07/2022
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Conversion or exercise price is in Canadian dollars.
(2) The options immediately vested.
(3) The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on October 7, 2015.
(4) The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on September 19, 2016.
(5) The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on March 30, 2021.
 
Remarks:
Exhibit List: Exhibit 24 - Power of Attorney

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